5-Lipoxygenase-Dependent Recruitment of Neutrophils and Macrophages by Eotaxin-Stimulated Murine Eosinophils
The roles of eosinophils in antimicrobial defense remain incompletely understood.In ovalbumin-sensitized mice, eosinophils are selectively recruited to the peritoneal cavity by antigen, eotaxin, or leukotriene(LT)B4, a 5-lipoxygenase (5-LO) metabolite.5-LO blockade prevents responses to both antigen and eotaxin.We examined responses to eotaxin in t